15-deoxyspergualin analogs, their method of preparation and...

C - Chemistry – Metallurgy – 07 – C

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C07C 279/12 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) C07C 279/24 (2006.01)

Patent

CA 2143216

The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin and which have the formula (see fig. I) in which: A is a single bond, a group -CH2-, a group -CH2O-, a group -CH2NH-, a group -CH(OH)-, a group -CHF- or a group -CH(OCH3)-, and n is equal to 6 or 8, and their addition salts. These novel compounds are useful especially as immunosuppressants. The invention further relates to the method of preparing said compounds.

L'invention concerne des composés qui sont des produits industriels nouveaux, ainsi que leurs sels d'addition. Ces composés sont reliés par leur structure à la 15-désoxyspergualine et ont la formule (voir fig. I) dans laquelle : A est une liaison simple, un groupement -CH2-, un groupement -CH20-, un groupement -CH2NH-, un groupement -CH(OH)-, un groupement -CHF- ou un groupement -CH(OCH3)-; et n est égal à 6 ou à 8. Ces composés nouveaux sont particulièrement utiles comme immunosuppresseurs. L'invention a aussi trait à la méthode de préparation de ces composés.

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