15-deoxyspergualin analogs, their use in therapeutics and...

C - Chemistry – Metallurgy – 07 – C

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C07C 279/12 (2006.01) A61K 31/16 (2006.01) C07C 247/12 (2006.01) C07C 271/20 (2006.01) C07C 279/14 (2006.01) C07C 279/24 (2006.01) C07D 309/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2187281

Compounds selected from the group consisting of (i) products of formula (I), wherein R is a hydrogen atom, an OH group, an OCH3 group or a CH2OH group, *C, when R is not a hydrogen atom, is an asymmetrical carbon atom having configuration (R,S), (R) or (S), and **C is an asymmetrical carbon atom having configuration (R,S) or (R); and (ii) addition salts thereof, are disclosed. A method for preparing said compounds, the use thereof in therapy and in the field of analysis, as well as intermediate products, are also disclosed.

La présente invention a trait à des composés choisis parmi l'ensemble constitué par: (i) les produits de formule (I) dans laquelle R représente un atome d'hydrogène, un groupe OH, un groupe OCH¿3? ou un groupe CH¿2?OH; *C, dans le cas où R n'est pas un atome d'hydrogène, est un atome de carbone asymétrique de configuration (R,S), (R) ou (S); **C est un atome de carbone asymétrique de configuration (R,S) ou (R), et (ii) leurs sels d'addition. Elle concerne également le procédé de préparation de ces composés, leur utilisation en thérapeutique et dans le domaine analytique ainsi que des produits intermédiaires.

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