C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/12 (2006.01) A61K 31/155 (2006.01) A61K 31/17 (2006.01) A61K 31/27 (2006.01) C07C 279/24 (2006.01) C07D 307/20 (2006.01)
Patent
CA 2110437
The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin. These novel compounds have the formula (see fig. I) in which: - n is equal to 6 or 8 and - A is a single bond, CH2, CHF, CH(OH), CH-(OCH3), CH2NH or CH2O, and their addition salts. These novel compounds are useful as immuno-suppressants.
La présente invention porte, dans le cadre de nouveaux produits industriels, sur des composés structurellement apparentés à la 15-désoxyspergualine. Ces nouveaux composés sont de formule (voir fig. I), dans laquelle n est égal à 6 ou 8, et A est une liaison simple, CH2, CHF, CH(OH), CH-(OCH3), CH2NH ou CH2O; l'invention porte aussi sur leurs sels d'addition avec un acide. Ces nouveaux composés sont utiles comme immunosuppresseurs.
Derrepas Philippe
Dutartre Patrick
Lebreton Luc
Renaut Patrice
Samreth Soth
Laboratoires Fournier S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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