C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/16 (2006.01) A61K 31/475 (2006.01) C07D 471/20 (2006.01)
Patent
CA 2057829
NOVEL 15 NITRO-2.beta.,3.beta.-DIHYDRO- AND 15-NITRO-2.beta.,3.beta.,6,7- -TETRAHYDROTABERSONINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME Abstract The invention relates to novel 15-nitro-2.beta.,3.beta.- -dihydro- and 15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine de- rivatives of the formula (I), Image (I) wherein R1 stands for hydrogen; R2 stands for hydrogen or a C1-6alkyl group; and the symbol Image represents a single or double bond as well as their salts. The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for the preparation of the above compounds of formula (I) and of the pharmaceutical compositions. The compounds of formula (I) exert a reducing or inhibitory effect on cerebral edema and show antihypoxic properties. Thus, they are useful for the prevention or treatment of brain injuries of various origin induced by hypoxia of the brain.
Barta Margit
Bodo Mihaly
Bolya Viktoria
Csomor Katalin
Galambos Janos
Barta Margit
Bodo Mihaly
Bolya Viktoria
Csomor Katalin
Fetherstonhaugh & Co.
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