15-substituted 4-azasteroids

Details 15-substituted 4-azasteroids 15-substituted 4-azasteroids

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01) C07J 1/00 (2006.01) C07J 21/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2157363

Compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 is -H or C1-10 alkyl; R2 is -H or C1-10 alkyl; R3 is C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxyl, cyano, or triphenylthio- C1-6 alkyl; and R4 is a mono-substituent or di-substituent are useful as inhibitors of 5.alpha.-reductase. These compounds can be used alone or in combination with other active agents to treat acne, androgenic alopecia, female hirsutism, benign prostatic hyperplasia, prostatitis, and treat and prevent prostatic carcinoma.

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