16-amino-18,19,20-trinor-prostaglandin derivatives, acid...

C - Chemistry – Metallurgy – 12 – P

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195/129, 260/235

C12P 31/00 (2006.01) C07C 405/00 (2006.01)

Patent

CA 1163586

ABSTRACT OF THE DISCLOSURE The invention relates to now 16-amino-18,19,20-trinor-prostaglandin derivatives of general formula I Image I having at C-17 a substituted or unsubstituted phenyl group, wherein C-15 and C-16 may have either S or R configuration, Y stands for a hydrogen atom or a lower alkyl group, W stands fo? a hydrogen atom, halogen atom, hydroxy group, lower alkyl or alkoxy group, and their acid addition salts. Those compounds can be prepared by removing the p-nitrobenzyloxycarbonyl protective group from a corresponding 9.alpha.,11.alpha.,15-trihydroxy-16-p-nitrobenzyloxycarbonylamido-17-pheny- 5-cis,13-trans-18,19,20-trinor-prostadienoic acid and the resulting product of general formula I is optionally converted with a suitable organic or inorganic acid into a pharmaceutically acceptable salt. The new prostaglandin derivatives of the invention have valuable therapeutic properties, and can be applied in cattle raising for estrus and ?th synchronization, and also in veterinary practice for the treatment of sterility, chronic endometritis and pyometry. The new prostaglandin derivatives of the invention have valuable therapeutical properties, and can be applied in cattle raising for estrus and birth synchronization furthermore in the veterinary praxis for the treatment of sterility, chronic endometritis and pyometry.

391747

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