16-membered macrolide derivatives and process for producing...

Details 16-membered macrolide derivatives and process for producing... 16-membered macrolide derivatives and process for producing...

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2127578

ABSTRACT OF THE DISCLOSURE 16-membered macrolide derivatives represented by the formula (I): Image (I) wherein R1 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R2 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R3 represents a hydrogen atom or a straight-chain aliphatic acyl group having 2 to 4 carbon atoms; and R4 represents a hydrogen atom or a straight-chain aliphatic or aromatic acyl group having 1 to 10 carbon atoms; or a pharmaceutically acceptable salt thereof are disclosed. A novel process for producing these 16-membered macrolide derivatives is also disclosed. - 226 -

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