16-phenoxy-and 16-substituted phenoxy-prostatrienoic acid...

Details 16-phenoxy-and 16-substituted phenoxy-prostatrienoic acid... 16-phenoxy-and 16-substituted phenoxy-prostatrienoic acid...

C - Chemistry, Metallurgy

07

F

260/235.03

C07F 9/40 (2006.01) C07C 405/00 (2006.01) C07D 307/935 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1064027

ABSTRACT OF THE DISCLOSURE Novel racemic and 8R-antimeric 16-phenoxy-and 16-(o , m or p)-substituted phenoxy derivatives of 9.alpha.,11.alpha., 15-trihydroxy-17,18,19,20-tetranorporsta-4,5,13-trans-trienoic acids, which may be further substituted at C-15 by a methyl or ethyl group, the pharmaceutically acceptable, non-toxic lower aklyl esters and salts thereof and processes for the production of such compounds. dl 9.alpha.,11.alpha.,15.alpha.-trihydroxy-16-m- trifluoromethylphenoxy-17,18,19,20-tetranorprosta-4,5,13- trans-trienoic acid and dl 9.alpha.,11.alpha.,15?-trihydroxy-15?-methyl- 16-m-trifluoromethylphenoxy-17,18,19,20-tetranorprosta-4,5, 13-trans-trienoic acid are representative compounds of the class. These compounds possess prostagladin-like activities and thus are useful in the treatment of mammals where pros- taglandins are indicated. They are particularly useful as luteolytic agents in female mammals.

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