16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1...

Details 16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1... 16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1...

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2173863

Compounds of formula (I) are inhibitors of the 5.alpha.-reductase 1 isozyme, and are useful alone, or in combination with a 5.alpha.-reductase 2 inhibitor. for the treatment of androgenic sensitive disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, and benign prostatic hyperplasia.

Les composés de la formule (I) sont des inhibiteurs de l'isozyme 5.alpha.-réductase 1 et s'utilisent individuellement ou en combinaison avec un inhibiteur de 5.alpha.-réductase 2, dans le traitement des troubles sensibles aux androgènes comme l'acné vulgaire, la séborrhée, l'hirsutisme, la calvitie hippocratique et l'hypotrophie bénigne de la prostate.

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