16-substituted-6-aza-steroid 5-.alpha.-reductase inhibitors

Details 16-substituted-6-aza-steroid 5-.alpha.-reductase inhibitors 16-substituted-6-aza-steroid 5-.alpha.-reductase inhibitors

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01) C07D 221/18 (2006.01)

Patent

CA 2233084

Compounds of formula (I) are inhibitors of 5.alpha.-reductase, and are useful for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, prostatic carcinoma, prostatitis and benign prostatic hyperplasia.

L'invention concerne des composés représentés par la formule (I). Ces composés sont des inhibiteurs de 5.alpha.-reductase, utiles dans le traitement d'un certain nombre de manifestations de l'hyperandrogénie, à savoir par exemple: acné vulgaire, séborrhée, virilisme pilaire, calvitie hypocratique, carcinome prostatique, prostatite et adénome prostatique.

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