17.alpha.-alkyl-17.beta.-oxy-estratrienes and intermediates...

C - Chemistry – Metallurgy – 07 – J

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C07J 41/00 (2006.01) A61K 31/567 (2006.01) A61P 5/32 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2468412

The invention relates to 17.alpha.-alkyl-17.beta.-oxy-estra-1,3,5(10)-trienes having an anti-oestrogen action, of general formula (I). The invention also relates to 17-oxo-estra-1,3,5(10)-trienes and 17.beta.-hydroxy-estra-1,3,5(10)- trienes as intermediates for producing the inventive estratrienes. The invention further relates to the use of 17.alpha.-alkyl-17.beta.-oxy- estratrienes for the production of medicaments and pharmaceutical preparations containing at least one 17.alpha.-alkyl-17.beta.-oxy-estratriene and at least one pharmaceutically acceptable carrier.

L'invention concerne des 17.alpha.-alkyl-17.beta.-oxy-estra-1,3,5(10)-triènes à action anti-oestrogène, de formule générale (I). L'invention concerne également des 17-oxo-estra-1,3,5(10)-triènes et des 17.beta.-hydroxy-estra-1,3,5(10)-triènes utilisés comme intermédiaires pour produire les estratriènes selon l'invention. L'invention concerne en outre l'utilisation des 17.alpha.-alkyl-17.beta.-oxy-estratriènes pour produire des médicaments, ainsi que des préparations pharmaceutiques contenant au moins un 17.alpha.-alkyl-17.beta.-oxy-estratriène et au moins un support pharmaceutiquement acceptable.

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