17-amino-16-hydroxy steroids of the androstane and oestrane...

Details 17-amino-16-hydroxy steroids of the androstane and oestrane... 17-amino-16-hydroxy steroids of the androstane and oestrane...

C - Chemistry, Metallurgy

07

J

260/28

C07J 41/00 (2006.01) C07J 1/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1167837

NOVEL 17-AMINO-16-HYDROXY STEROIDS OF THE ANDROSTANE AND OESTRANE SERIES AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS. ABSTRACT New and pharmacologically useful 17-amino-16- hydroxy-steroids of the androstane and oestrane series are disclosed having the formula I: Image I and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: R1 = H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R2 = H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R3 = a free, esterified or etherified hydroxyl group; ring A inclusive carbon atoms 6 and 9 has one of ? Image in which R4 = a free, esterified or etherified hydroxyl group; R5 = O or H(R7), wherein R7 is a free, esterified or etherified hydroxyl group; R6 = H or methyl; and the dotted lines represent an optional double bond in 4,5- or 5,6-position; as well as the enantiomers and racemates of these steroids. The novel compounds have antiarrhythmic properties.

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