17-amino substituted 4-azasteroid 5a-reductase inhibitors

C - Chemistry – Metallurgy – 07 – J

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C07J 73/00 (2006.01) A61K 31/58 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2135057

2135057 9323038 PCTABS00028 Novel amino substituted 4-azasteroid 5.alpha.-reductase inhibitors of formula (I), wherein A is (a), (b) or (c), are claimed as well as pharmaceutically acceptable salts and formulations thereof. These compounds are effective in inhibiting testosterone 5.alpha.-reductase(s) and are thus useful in the treatment of a number of hyperandrogenic conditions including benign prostatic hypertrophy, acne, seborrhea, female hirsutism, and male and female pattern baldness (alopecia).

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