C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01) A61K 31/58 (2006.01)
Patent
CA 2044914
8368/SCM103 18140 TITLE OF THE INVENTION NEW 17.beta.-AMINOBENZOYL-4-AZA-5a-ANDROST-1- EN-3-ONES AS BENIGN PROSTATIC HYPERTROPHY AGENTS ABSTRACT OF THE INVENTION NEW 17.beta.-AMINOBENZOYL-4-AZA-5a-ANDROST-1- EN-3-ONES AS BENIGN PROSTATIC HYPERTROPHY AGENTS OF THE FORMULA: Image (I) 8368/SCM103 1814 wherein R is selected from hydrogen, methyl and ethyl and R2 is phenyl substituted with -N(R3)2, which can be protected, where R3 is independently or C1-C4 alkyl, wherein the phenyl ring can also be further substituted by C1-C4 alkyl, wherein the dotted line can represent a double bond, and pharmaceutically accept- able salts thereof, and a pharmaceutical formulation thereof. The above compounds are active as benigh prostatic hypertrophy therapy agents and are useful topically for the treatment of acne, seborrhea, female hirsutism, and particularly effective systemically in the treatment of benign prostatic hypertrophy.
Rasmusson Gary H.
Salzmann Thomas N.
Steinberg Nathan G.
Merck & Co. Inc.
Rasmusson Gary H.
Salzmann Thomas N.
Steinberg Nathan G.
Swabey Ogilvy Renault
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