17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy...

C - Chemistry – Metallurgy – 07 – J

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C07J 71/00 (2006.01) A61K 31/58 (2006.01) A61P 5/44 (2006.01) A61P 29/00 (2006.01) C07J 3/00 (2006.01) C07J 17/00 (2006.01) C07J 31/00 (2006.01) C07J 33/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2417826

There are provided according to the invention compounds of formula (I) wherein R1 represents C1-6 alkyl or C1-6 haloalkyl; R2 represents -C(=O)-aryl or - C(=O)-heteroaryl; R3 represents hydrogen, methyl (which may be in either the .alpha. or .beta. configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and ---- represents a single or a double bond; and salts and solvates thereof. There are also provided processes for preparing compounds of formula (I) and use of the compounds in therapy especially in the treatment of inflammatory and allergic conditions.

L'invention concerne des composés représentés par la formule (I) dans laquelle R¿1? représente C¿1-6? alkyle ou C¿1-6? haloalkyle; R¿2? représente -C(=O)-aryle ou -C(=O)-hétéroaryle; R¿3? représente hydrogène, méthyle (lequel peut avoir la forme .alpha. ou la forme .beta.) ou méthylène; R¿4? et R¿5? sont identiques ou différents et représentent chacun hydrogène ou halogène; et ---- représente une liaison simple ou double; et des sels et des solvates de ceux-ci. L'invention concerne également des procédés permettant de préparer les composés représentés par la formule (I), ainsi que l'utilisation de ces composés à des fins thérapeutiques, plus particulièrement, pour le traitement d'affection inflammatoires et allergiques.

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