C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61K 31/58 (2006.01) A61P 5/32 (2006.01) C07J 43/00 (2006.01) C07J 71/00 (2006.01)
Patent
CA 2609726
The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17.beta.-hydroxysteroid dehydrogenase type I (17.beta.-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17.beta.-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17.beta.-estradiol concentration.
L'invention concerne de nouveaux dérivés stéroïdes substitués qui représentent des inhibiteurs sélectifs de 17.beta.-hydroxystéroïde déshydrogénase type I (17.beta.-HSD1) et, en outre, qui peuvent représenter des inhibiteurs de stéroïde sulfatase. Elle concerne également leurs sels, les préparations pharmaceutiques contenant ces composés ainsi que les processus de préparation de ces composés. De plus l'invention concerne l'utilisation thérapeutique de ces nouveaux dérivés stéroïdes substitués, en particulier leur utilisation dans le traitement ou la prévention de maladies ou troubles liés aux hormones stéroïdiennes, tels que ceux nécessitant l'inhibition de 17.beta.-hydroxystéroïde déshydrogénase type I et/ou des enzymes de stéroïde sulfatase et/ou l'abaissement de la concentration de 17.beta.-estradiol endogène.
Husen Bettina
Kallio Lila
Koskimies Pasi
Messinger Josef
Thole Heinrich-Hubert
Mccarthy Tetrault Llp
Solvay Pharmaceuticals Gmbh
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