17.beta.-n-monosubstituted...

C - Chemistry – Metallurgy – 07 – J

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C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2058920

99/RJN51 - i - 18052 Canada TITLE OF THE INVENTION 17-N-MONOSUBSTITUTED ADAMANTYL/NORBORNANYL CARBAMOYL-4-AZA-5.alpha.-ANDROST-1-EN-3-ONES AND ANDROSTAN-3-ONES AS 5.alpha. REDUCTASE INHIBITORS ABSTRACT OF THE INVENTION 17.beta.-N-MONOSUBSTITUTED ADAMANTYL/NORBORNANYL CARBAMOYL-4-AZA-5.alpha.-ANDROST-1-EN-3-ONES AND ANDROSTAN-3 ONES AS 5.alpha. REDUCTASE INHIBITORS OF THE FORMULA: Image I 99/RJN51 - ii - 18052 Canada wherein R is selected from hydrogen, methyl and ethyl and R2 is a hydrocarbon radical selected from sub- stituted or unsubstituted 1- or 2-adamantyl or 1- or 2-norbornanyl and wherein the dotted line represents a double bond which can be present.

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