17.beta.-n-monosubstituted-carbamoyl-4-aza-5.alpha.-androsta...

Details 17.beta.-n-monosubstituted-carbamoyl-4-aza-5.alpha.-androsta... 17.beta.-n-monosubstituted-carbamoyl-4-aza-5.alpha.-androsta...

C - Chemistry, Metallurgy

07

J

167/195, 260/3

C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 1284636

TITLE OF THE INVENTION OXIDIZED ANALOGS OF 17B-N-MONOSUBSTITUTED CARBAMOYL-4-AZA-5.alpha.-ANDROSTAN-3-ONES ABSTRACT OF THE INVENTION: The compounds of formula (I) Image (I) wherein R is selected from hydrogen, methyl or ethyl, and R1 is C1-12 straight or branched chain alkyl wherein one of the hydrogens is substituted by hydroxy, carboxylic acid or C1-4 alkyl ester, and A is -CH2-CH2 or -CH=CH-, and pharmaceutical formulations of the above compounds are active as testosterone 5.alpha.-reductase inhibitors and thus are useful for treatment of acne, seborrhea, female hirsutism o? benign prostatic hypertrophy.

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