17.beta.-(substituted thio)androstenes

C - Chemistry – Metallurgy – 07 – J

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167/198, 260/28.

C07J 31/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 1245215

ABSTRACT 17.beta.-(SUBSTITUTED THIO)ANDROSTENES Antiinflammatory activity is exhibited by new steroids having the formula Image or the 1,2-dehydro derivative thereof, wherein R1 is alkyl, alkanoyloxyalkyl, arylcarbonyloxy- alkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl; R2 is hydrogen, hydroxy, alkoxy, aryloxy, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or halogen; R3 is hydrogen, methyl, hydroxy or halogen; and n is 0, 1 or 2.

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