17.beta.-(substituted thio)androstenes

Details 17.beta.-(substituted thio)androstenes 17.beta.-(substituted thio)androstenes

C - Chemistry, Metallurgy

07

J

260/28.4

C07J 31/00 (2006.01)

Patent

CA 1257250

ABSTRACT The invention relates to novel intermediates of the formula Image or the 1,2-dehydro derivative thereof, wherein R2 is hydrogen, hydroxy, alkoxy, aryloxy, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or halogen; R3 is hydrogen, methyl, hydroxy or halogen; which are used in the preparation of new steroid compounds having the formula Image or the 1,2-dehydro derivative thereof, wherein R1 is alkyl, alkanoyloxyalkyl, arylcarbonyloxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl; R2 and R3 are as defined above; and n is 0, 1 or 2. The latter are useful since they possess topical anti-inflammatory activity.

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