C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01) A61K 31/436 (2006.01) C07D 221/00 (2006.01) C07D 273/00 (2006.01) C07D 311/00 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2575582
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in. one aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods_ for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17~desinethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections,. transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.
L'invention concerne la production de polyketides et d'autres produits naturels, ainsi que des banques de composés et des nouveaux composés individuels. Selon un aspect, l'invention concerne la 17-desméthylrapamycine et des analogues de celle-ci, leurs procédés de production, y compris des souches recombinées, et l'isolation et des utilisations des composés de l'invention. L'invention concerne en outre l'utilisation de la 17-desméthylrapamycine et des analogues de celle-ci dans l'induction ou le maintien de l'immunosuppression, la stimulation de la régénération neuronale ou le traitement du cancer, les tumeurs malignes associées aux lymphocytes B, les infections fongiques, le rejet de greffe, la maladie du greffon contre l'hôte, les troubles auto-immuns, les maladies inflammatoires et les maladies fibreuses, et dans la régulation de la cicatrisation.
Gregory Matthew Alan
Martin Christine Janet
Biotica Technology Limited
Smart & Biggar
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