17-ethers and thioethers of 4-aza-steroids

C - Chemistry – Metallurgy – 07 – J

Patent

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C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2135174

2135174 9323040 PCTABS00028 Compounds of formula (I), wherein Z contains an ether or thioether moiety, are inhibitors of the 5.alpha.-reductase enzyme and isozymes thereof. The compounds are useful for the treatment of hyperandrogenic disease conditions and diseases of the skin and scalp.

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