C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 53/00 (2006.01) A61K 31/585 (2006.01) A61P 5/34 (2006.01)
Patent
CA 2710491
The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid .gamma.- lactone derivatives with the chemical formula I, where R4, R6, R6b, R7, R15, R16a, R16b, R18 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action. (see formula I)
L'invention concerne des dérivés de 17-hydroxy-19-nor-21-acide carboxylique-stéroïde ?-lactone de formule chimique (I), où R4, R6a, R6b, R7, R15, R16a, R16b, R18 et Z ont les significations indiquées dans la revendication 1, ainsi que leurs solvates, hydrates, stéréoisomères et sels. L'invention concerne en outre : l'utilisation de ces dérivés pour la fabrication d'un médicament destiné à la contraception orale et au traitement de troubles pré-ménopausiques, péri-ménopausiques et post-ménopausiques ; et des médicaments qui contiennent de tels dérivés. Les dérivés selon l'invention présentent une action gestagène et en outre, dans des cas préférés, une action antiminéralocorticoïde et neutre à légèrement androgène.
Bohlmann Rolf
Borden Steffen
Frenzel Thomas
Huebner Jan
Klar Ulrich
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
LandOfFree
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