17-methylene-androstan-3alpha-ol analogs as crh inhibitors

Details 17-methylene-androstan-3alpha-ol analogs as crh inhibitors 17-methylene-androstan-3alpha-ol analogs as crh inhibitors

A - Human Necessities

61

K

A61K 31/568 (2006.01) A61K 31/565 (2006.01) A61K 31/5685 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2484596

17-Methylene-androstan-3.alpha.-ol analogs are useful as corticotropin releasing hormone (CRH) inhibitors, and especially as anti-depressants, when administered to the vomeronasal organ. An improved synthesis of 17- methyleneandrost-4-en-3.alpha.-ol is disclosed.

L'invention concerne des analogues de 17-méthylène-androstan-3.alpha.-ol pouvant servir d'inhibiteurs de l'hormone de libération de la corticotrophine (CRH), et plus particulièrement, d'antidépresseurs lorsqu'ils sont administrés à l'organe voméro-nasal. L'invention concerne en outre une synthèse améliorée de 17-méthylèneandrost-3.alpha.-ol.

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