17-spirofuran-3'-ylidene steroids

C - Chemistry – Metallurgy – 07 – J

Patent

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C07J 21/00 (2006.01) A61K 31/58 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2084431

The invention relates to an antiprogestin 17-spirofuran- 3'-ylidene steroid having the formula Image wherein R1 is NR2R3, lower acyl, OH, SH, O-lower alkyl or S(O)n- lower alkyl wherein n is 0-2; R2 and R3 are independently selected from hydrogen and lower alkyl; R4 is hydrogen or lower alkyl; R5 is O, (H, H), (H,OH), (H,O-lower acyl), or NOH; R6 and R7 are both hydrogen, or one is hydrogen and the other lower alkyl: and the twitched line represents an .alpha. or .beta. bond.

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