17-substituted androsta-1,4-dien-3-one derivatives

Details 17-substituted androsta-1,4-dien-3-one derivatives 17-substituted androsta-1,4-dien-3-one derivatives

C - Chemistry, Metallurgy

07

J

167/192, 260/39

C07J 1/00 (2006.01) A61K 31/565 (2006.01) C07J 17/00 (2006.01) C07J 31/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1305699

A B S T R A C T The invention relates to new 17-hydroxy androsta-1,4- -diene-3-one derivatives of the following formula Image (I) wherein each of R and R3, independently, is hydrogen or C1-C6 alkyl; R1 is hydrogen, halogen or C1-C6 alkyl; R2 is hydrogen or C1-C6 alkyl; R4 is hydrogen or fluorine; R5 is a) hydrogen or C1-C6 a1ky1; b) phenyl unsubstituted or substituted by one or two substituents independently chosen from C1-C6 alkyl, halogen and amino; c) an acyl group; or d) a hydroxy protecting group; and the pharmaceutically acceptable salt thereof, which are useful in therapy, in particular as anti-cancer agents.

576898

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