17 - substituted steroids useful in cancer treatment

Details 17 - substituted steroids useful in cancer treatment 17 - substituted steroids useful in cancer treatment

C - Chemistry, Metallurgy

07

J

C07J 43/00 (2006.01) A61K 31/58 (2006.01) C07J 13/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2132449

Compounds of general formula (1) wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R14 represents a hydrogen atom and R15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R14 and R15 together represent a double bond, and R16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or pharmaceutically acceptable acid addition salts, with the proviso that 17-(3-pyridyl)androsta- 5,14,16-trien-3.beta.-ol and 15.beta.-acetoxy-17-(3-pyridyl)androsta-5,16-dien- 3.beta.-ol and their 3-acetates and 3.beta.-methoxy-17-(3-pyri- dyl)androst-16-ene are claimed only for use in therapy are useful for treatment of androgen-dependent disorders, especially pros- tatic cancer, and also oestrogen-dependent disorders such as breast cancer.

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