17alpha-hydroxy-14beta-steroids with hormonal effect

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 1/00 (2006.01) A61K 31/565 (2006.01) A61P 5/26 (2006.01) C07J 41/00 (2006.01) C07J 69/00 (2006.01)

Patent

CA 2505575

This invention relates to steroidal compounds having the formula (I), wherein: R1 is O, (H,H), (H,OH), NOH, whereby OH is optionally etherified or esterified; R2 and R3 are independently hydrogen or (C1-4) alkyl and at least one of R2 and R3 is (C1-4) alkyl; R4 is hydrogen, or (C1-15) acyl for use in androgen-related treatments, such as androgen insufficiency and male or female contraception.

L'invention concerne des composés stéroïdes représentés par la formule (I), dans laquelle R<1> représente O, (H,H), (H,OH), NOH, OH étant éventuellement ethérifié ou estérifié; R<2> et R<3> représentent chacun indépendamment hydrogène ou (C1-4) alkyle et au moins l'un de R<2> et R<3> représente (C1-4) alkyle; R<4> représente hydrogène, ou (C1-15) acyle. On utilise lesdits composés pour des traitements associés à un androgène, tel que le traitement de l'insuffisance androgénique et la contraception masculine ou féminine.

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