17beta-substituted aza-androstane derivatives

C - Chemistry – Metallurgy – 07 – J

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C07J 73/00 (2006.01)

Patent

CA 2080054

4-18806/A Novel substituted aza-androstane derivatives Abstract Compounds of the formula Image (l) wherein carbon atoms 1 and 2 are linked by a single bond or a double bond, R1 ishydrogen, methyl or ethyl, and A is a group or the formula -N(-R2)-X- wherein R2 is hydrogen or C1-C4alkyl and X is C1-C12alkylene or C3-C6,cycloalkylidene; a group of the formula -N(-R2)-Y-Phe- wherein R2 is as defined above, Y is a direct bond or C1-C6- alkylene and Phe is an unsubstituted of substituted phenylene radical; a group of the formula -O-X- wherein X is as defined above, or a group -O-Y-Phe- wherein Y and Phe are as defined above, are inhibitors of 5.alpha.-reductase and can be used for the therapeutic treatment of the human and animal body.

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