18-membered macrocycles and analogs thereof

Details 18-membered macrocycles and analogs thereof 18-membered macrocycles and analogs thereof

A - Human Necessities

61

K

A61K 31/7048 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2596387

The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.

La présente invention se rapporte d'une manière générale aux agents anti-microbiens macrocycliques à 18 chaînons appelés tiacumicines, spécifiquement à l'OPT-80 (qui se compose presque entièrement de la R-tiacumicine B), à des compositions pharmaceutiques comprenant de l'OPT-80 et à des procédés d'utilisation de l'OPT-80. En particulier, ce composé est un médicament puissant pour le traitement des infections bactériennes, spécifiquement des infections à C. difficile.

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