18f-labelled folates

Details 18f-labelled folates 18f-labelled folates

C - Chemistry, Metallurgy

07

D

C07D 475/04 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2670379

The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

La présente invention concerne des nouveaux produits radiopharmaceutiques de type 18F-folates, dans lesquels le fluor 18 est lié par covalence à un fragment aminobenzoyle, qui raccorde l'hétérocycle pyrimidine condensé à la partie acide aminé à l'intérieur de structures folates, ainsi que leurs précurseurs et leurs références non radioactives, un procédé de préparation de ceux-ci, ainsi que leur utilisation pour le diagnostic d'une cellule ou d'une population de cellules exprimant un récepteur de folate et pour la surveillance et le traitement du cancer et de maladies inflammatoires et auto-immunes.

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