C - Chemistry – Metallurgy – 07 – B
Patent
C - Chemistry, Metallurgy
07
B
C07B 59/00 (2006.01) A61B 5/00 (2006.01) C07D 475/04 (2006.01)
Patent
CA 2670363
The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18 [F] fluoride, as well as 18F-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.
La présente invention concerne un nouveau procédé de synthèse de produits radiopharmaceutiques de type 18F-folates, dans lequel le fluor 18 est fixé à un ptéroate (ou folate) ou un dérivé de celui-ci, par radiomarquage direct au fluor [F] 18, ainsi que des produits radiopharmaceutiques de type 18F-folates obtenus selon ledit procédé de synthèse et leur utilisation pour le diagnostic et le contrôle du traitement du cancer et le traitement de maladies inflammatoires et auto-immunes.
Ametamey Simon Mensah
Groehn Viola
Lam Phoebe
Moser Rudolf
Ross Tobias Ludwig
Merck & Cie
Merck Eprova Ag
Riches Mckenzie & Herbert Llp
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