18f-labelled folates

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 475/04 (2006.01) A61K 51/04 (2006.01)

Patent

CA 2670371

The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.

La présente invention concerne des nouveaux produits radiopharmaceutiques de type 18F-folates, dans lesquels le fluor 18 est lié par covalence par l'intermédiaire d'un liant triazole ou tétrazole à un folate ou un dérivé de celui-ci, un procédé de préparation de ceux-ci, ainsi que leur utilisation pour le diagnostic et la surveillance du traitement du cancer et de maladies inflammatoires et auto-immunes.

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