C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 475/04 (2006.01) A61K 51/04 (2006.01)
Patent
CA 2670371
The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
La présente invention concerne des nouveaux produits radiopharmaceutiques de type 18F-folates, dans lesquels le fluor 18 est lié par covalence par l'intermédiaire d'un liant triazole ou tétrazole à un folate ou un dérivé de celui-ci, un procédé de préparation de ceux-ci, ainsi que leur utilisation pour le diagnostic et la surveillance du traitement du cancer et de maladies inflammatoires et auto-immunes.
Ametamey Simon Mensah
Groehn Viola
Mindt Thomas Leighton
Moser Rudolf
Ross Tobias Ludwig
Merck & Cie
Merck Eprova Ag
Riches Mckenzie & Herbert Llp
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