18f-labelled folates as pet radiotracers

Details 18f-labelled folates as pet radiotracers 18f-labelled folates as pet radiotracers

C - Chemistry, Metallurgy

07

D

C07D 475/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2736861

The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.

La présente invention concerne de nouveaux produits radiopharmaceutiques de 18F-folates, dans lesquels du 18fluor est lié par covalence à la partie glutamate d'un folate ou d'un de ses dérivés, un procédé pour les préparer, ainsi que leur utilisation dans le diagnostic et le suivi d'une thérapie contre le cancer et des maladies inflammatoires et auto-immunes.

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