C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
167/191, 260/31,
C07J 53/00 (2006.01) A61K 31/56 (2006.01) C07J 21/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01) C07J 63/00 (2006.01) C07J 71/00 (2006.01)
Patent
CA 1326015
(1) ABSTRACT New 19,11.beta.-bridged steroids of the general formula I Image (I), where R1 stands for a methyl or ethyl radical, R2 for a hydrogen or chlorine atom or a C1-C4-alkyl radical, B and G, which are the same or different, respectively for a hydrogen atom, a C1-C4-alkyl radical or, together, for a sec- ond bond between the carbon atoms 6 and 7, B and R2 together for a methylene or an ethylene group, Z for the radical of a pentagonal or hexagonal ring, which is possibly substituted and possibly unsaturated, V stands for a possibly substituted carbocyclic or hetero- cyclic aryl radical, the ring A for a) Image (2) M and N together meaning a second bond or M a hydrogen atom and N a hydroxy group, X means an oxygen atom, two hydrogen atoms or a hydroxyimino grouping N?OH, R3 and D, which are the same or different, respectively a hy- drogen atom, a nitrile radical or a C1-C4-alkyl radical or, together, a methylene or ethylene group, E a hydrogen atom or a C1-C4-alkyl radical, D and E together meaning a second bond between carbon atoms 1 and 2 or together a methylene group or b) Image or c) Image with R11 in the meaning of a hydrogen atom or a C1-C8-alkyl radical, are described as well as their pharmaceutically tolerated ad- dition salts with acids. The new compounds possess valuable pharmacological properties.
561771
Beier Sybille
Elger Walter
Henderson David Andrew
Neef Gunter
Ottow Eckhard
Marks & Clerk
Schering Aktiengesellschaft
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