19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring

Details 19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring 19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring

C - Chemistry, Metallurgy

07

D

C07D 311/74 (2006.01) A61K 31/352 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2647981

19-nor-vitamin D analogs having an additional heterocyclic ring connecting the 3.beta.-oxygen and carbon-2 or the 1.alpha.-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit significant activity in mobilization of bone, making them therapeutic agents for the treatment or prophylaxis of osteoporosis, osteomalacia, osteopenia, renal osteodystrophy and hypoparathyroidism.

L'invention concerne des analogues de la 19-nor-vitamine D, qui présentent un noyau hétérocyclique supplémentaire reliant le 3.beta.-oxygène et le carbone-2 ou le l.alpha.-oxygène et le carbone-2 du noyau A de l'analogue; et leurs utilisations pharmaceutiques. Ces composés présentent une activité considérable de mobilisation de l'os, ce qui en fait des agents thérapeutiques destinés au traitement ou à la prophylaxie de l'ostéoporose, l'ostéomalacie, l'ostéopénie, l'ostéodystrophie rénale et l'hypoparathyroïdie.

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