19-nor-vitamin d compounds

Details 19-nor-vitamin d compounds 19-nor-vitamin d compounds

C - Chemistry, Metallurgy

07

C

167/147, 260/581

C07C 401/00 (2006.01) A61K 31/59 (2006.01)

Patent

CA 1333616

This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.

612519

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