19-thio-androstane derivatives

Details 19-thio-androstane derivatives 19-thio-androstane derivatives

C - Chemistry, Metallurgy

07

J

260/38

C07J 31/00 (2006.01)

Patent

CA 1199023

ABSTRACT The invention relates to novel 19-thio-androstane derivatives having the general formula: Image and the 4,5-dihydro analogues thereof, wherein R1 = H, hydrocarbyl(1-4C), aralkyl(7-9C), aryl(6-9C) or acyl derived from an organic carboxylic acid having 1-18 C atoms; R2 = O, .alpha.R4(.beta.R3) or an acetal group; R3 = a free, esterified or etherified hydroxyl group; and R4 = H or hydrocarbyl(1-4C); and wherein the broken lines indicate the optional presence of a double bond in the 1,2-position and/or 6,7-position,and to processes for obtaining same. The novel compounds possess aromatase-inhibiting properties.

431742

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