C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 401/00 (2006.01) A61K 31/59 (2006.01)
Patent
CA 2420026
This invention discloses 1.alpha.-hydroxy-2-methylene-19-nor- homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte this evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
L'invention concerne 1.alpha.-hydroxy-2-méthylène-19-nor-homoprégnacalciférol et les applications thérapeutiques de ce composé. Ledit composé est très efficace pour stopper la prolifération de cellules non différentiées et provoquer leur différentiation par rapport au monocyte. Par conséquent, ledit composé est particulièrement adapté à la lutte contre le cancer et au traitement de maladies de la peau telles que le psoriasis, et d'affections de la peau telles que les rides, la peau détendue, la peau sèche, et une sécrétion insuffisante de sébum. Ledit composé présente également une activité calcémique faible, voire nulle, et peut par conséquent servir au traitement de maladies auto-immunes chez l'humain ainsi que de l'ostéodystrophie rénale.
Clagett-Dame Margaret
Deluca Hector F.
Gowlugari Sumithra
Plum Lori A.
Sicinski Rafal R.
Borden Ladner Gervais Llp
Wisconsin Alumni Research Foundation
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