1h-1,2,4-triazole-3-carboxamide derivatives as...

Details 1h-1,2,4-triazole-3-carboxamide derivatives as... 1h-1,2,4-triazole-3-carboxamide derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 249/10 (2006.01) A61K 31/41 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2491394

The present invention relates to a group of 1H-1,2,4-triazole-3-carboxamide derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing at least one of these compounds as an active ingredient. These 1H-1,2,4-triazole-3-carboxamide derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists, inverse agonists or antagonists, useful for the treatment of disorders involving cannabinoid neurotransmission. The compounds have the general formula (I), wherein R and R1-R3 have the meanings given in the specification.

La présente invention porte sur un groupe de dérivés de 1H-1,2,4-triazole-3-carboxamide, sur des procédés de préparation de ces composés et sur des compositions pharmaceutiques contenant au moins un de ces composés comme ingrédient actif. Ces dérivés de 1H-1,2,4-triazole-3-carboxamide sont de puissants agonistes partiels, agonistes ou antagonistes inverses du récepteur des cannabinoïdes-CB¿1? utiles dans le traitement des troubles affectant la neurotransmission des cannabinoïdes. Ces composés ont la formule générale (I) dans laquelle R et R¿1?-R¿3? sont tels que définis dans le descriptif.

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