1h-benzimidazole-4-carboxamides substituted with a...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/454 (2006.01) A61K 31/55 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2603784

Compounds of Formula (I) (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

L'invention concerne des composés de formule (I) inhibant l'enzyme PARP et utilisés pour le traitement d'une maladie ou d'un trouble associé(e) à PARP. L'invention concerne en outre des compositions pharmaceutiques comprenant des composés de formule (I), des méthodes de traitement comprenant les composés de formule (I), et des méthodes d'inhibition de l'enzyme PARP comprenant des composés de formule (I).

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