1h-benzimidazole-4-carboxamides substituted with phenyl at...

Details 1h-benzimidazole-4-carboxamides substituted with phenyl at... 1h-benzimidazole-4-carboxamides substituted with phenyl at...

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/4178 (2006.01) A61K 31/454 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2623822

Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).

L'invention concerne des composés représentés par la formule générale (I), inhibant l'enzyme PARP, utiles pour le traitement d'une maladie ou d'un trouble associé à la PARP. L'invention concerne également des compositions pharmaceutiques comprenant les composés représentés par la formule générale (I), des méthodes de traitement dans lesquelles sont utilisés les composés représentés par la formule générale (I), ainsi que des méthodes destinées à l'inhibition de l'enzyme PARP, dans lesquelles sont utilisés les composés représentés par la formule générale (I).

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