1h-benzimidazole-5-carboxamides as anti-inflammatory agents

Details 1h-benzimidazole-5-carboxamides as anti-inflammatory agents 1h-benzimidazole-5-carboxamides as anti-inflammatory agents

C - Chemistry, Metallurgy

07

D

C07D 235/30 (2006.01) A61K 31/4184 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2738083

There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.

La présente invention concerne les composés de formule (I), dans laquelle R1, R6, R8, Q2, Q3, Q3a, Q4, L et A ont les significations données dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, lesquels composés sont utiles dans le traitement de maladies dans lesquelles l'inhibition de l'activité d'un élément de la famille des MAPEG est souhaitée et/ou nécessaire, et en particulier dans le traitement d'une inflammation et/ou d'un cancer.

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