(1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives...

Details (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives... (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/46 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) A61P 37/00 (2006.01) C07D 235/24 (2006.01) C07D 263/58 (2006.01) C07D 277/68 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 451/04 (2006.01)

Patent

CA 2497827

(1H-Benzoimidazol-2-YL)-(Piperazinyl)-Methanone derivatives of formula (I) and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders (I) wherein B and B1 are C or up to one of B and B1 may be N; Y is O, S or NR2, where R2 is H or C1-4alkyl; Z is O or S; R8 is H and R9 is (a), where R10 Is H or C1-4alkyl, or R8 and R9 are taken together with their N of attachment to form (b); n is 1 or 2; m is 1 or 2; n + m is 2 or 3; other substituents as defined in claim 1.

L'invention concerne certains composés de thiénopyrrolyle et de furanopyrrolyle, utiles pour traiter ou prévenir des troubles et des affections dans lesquels intervient le récepteur H¿4 ?de l'histamine, y compris la rhinite allergique.

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