1h-imidazo[4,5-c]quinolin-4-amines

C - Chemistry – Metallurgy – 07 – D

Patent

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260/273.5, 260/2

C07D 471/04 (2006.01) A61K 31/47 (2006.01) C07D 215/42 (2006.01)

Patent

CA 1271477

ABSTRACT OF THE DISCLOSURE Compounds of the formula Image are disclosed, wherein R1 is selected from the group consisting of alkyl of one to about ten carbon atoms, hydroxyalkyl of one to about six carbon atoms, acyloxyalkyl wherein the acyloxy moiety is alkanoyloxy of two to about four carbon atoms or benzoyloxy, and the alkyl moiety contains one to about six carbon atoms, benzyl, (phenyl)ethyl and phenyl, said benzyl, (phenyl)ethyl or phenyl substituent being optionally substituted on the benzene ring by one or two moieties independently selected from the group consisting of alkyl of one to about four carbon atoms, alkoxy of one to about four carbon atoms, and halogen, with the proviso that if said benzene ring is substituted by two of said moieties, then said moieties together contain no more than 6 carbon atoms; R2 is selected from the group consisting of hydrogen and alkyl of one to about eight carbon atoms; and each R is independently selected from the group consisting of alkoxy of one to about four carbon atoms, halogen and alkyl of one to about four carbon atoms, and n is an integer from 0 to 2, with the proviso that if n is 2, then said R groups together contain no more than 6 carbon atoms. These compounds and their acid addition salts are useful as antiviral agents.

467706

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