1h-imidazole derivatives as cannabinoid cb2 receptor modulators

Details 1h-imidazole derivatives as cannabinoid cb2 receptor modulators 1h-imidazole derivatives as cannabinoid cb2 receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 233/90 (2006.01) A61K 31/4164 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2597896

The invention relates to a group of 1 H-imidazole derivatives which are modulators of cannabinoid CB2 receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1 H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which cannabinoid CB2 receptors are involved. The compounds have the general formula (I) wherein R1-R4 have the meanings given in the specification.

L'invention concerne un groupe de dérivés de 1 H-imidazole qui sont des modulateurs de récepteurs cannabinoïdes CB2, des procédés pour la préparation de ces composés, de nouveaux intermédiaires utiles pour la synthèse desdits dérivés de l~imidazole, des procédés pour la préparation de ces intermédiaires, des compositions pharmaceutiques contenant une ou plusieurs de ces dérivés de 1 H-imidazole en tant que principe actif, ainsi que l~utilisation de ces compositions pharmaceutiques pour le traitement de troubles dans lesquels sont impliqués des récepteurs cannabinoïdes CB2. Les composés ont la formule générale (I) dans laquelle R1 à R4 ont les significations indiquées dans la description.

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