1h-imidazole derivatives as cannabinoid receptor modulators

Details 1h-imidazole derivatives as cannabinoid receptor modulators 1h-imidazole derivatives as cannabinoid receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 233/90 (2006.01) A61K 31/417 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2534824

The invention relates to a group of 1H -imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders in which cannabinoid receptors are involved. The compounds have the general formula (I) wherein R, R1-R4 and X have the meanings given in the specification.

L'invention concerne un groupe de dérivés de 1H -imidazole qui sont des modulateurs de récepteurs cannabinoïdes, des procédés de préparation de ces composés, des intermédiaires utiles pour la synthèse des dérivés en question, des procédés de préparation des intermédiaires, des compositions pharmaceutiques renfermant un ou plusieurs dérivés comme principe actif, et l'utilisation de ces compositions pharmaceutiques pour le traitement de troubles psychiatriques et neurologiques faisant intervenir les récepteurs cités. Les composés sont de formule générale (I) sachant que R, R¿1?-R¿4? et X sont tels que spécifés dans la description.

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