C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/4164 (2006.01) A61P 25/00 (2006.01) C07C 257/18 (2006.01) C07D 233/90 (2006.01) C07D 295/30 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2457444
AbstractThe present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component.These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission.The compounds have the general formula (I) wherein R and R1-R4 have the meanings given in the specification.
L'invention concerne un groupe de nouveaux dérivés de 1H-imidazole, des procédés de préparations desdits composés, et des préparations pharmaceutiques contenant au moins un desdits composés en tant que composant actif. Lesdits dérivés de 1H-imidazole sont des agonistes, des agonistes partiels ou des antagonistes puissants du récepteur cannabinoïde CB1, utiles pour le traitement de troubles psychiatriques et neurologiques ainsi que d'autres maladies impliquant la neurotransmission cannabinoïde. Les composés de l'invention sont représentés par la formule générale (1), dans laquelle R et R¿1?-R¿4? possèdent les significations données dans la description
Herremans Arnoldus H.j.
Kruse Cornelis G.
Lange Josephus H.m.
Van Stuivenberg Herman H.
Fetherstonhaugh & Co.
Solvay Pharmaceuticals B.v.
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