1h-imidazopyridine derivatives

Details 1h-imidazopyridine derivatives 1h-imidazopyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) C07D 471/14 (2006.01) C07D 491/113 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2339562

1H-Imidazopyridine derivatives represented by general formula (I); or salts thereof (wherein R1 is hydrogen, hydroxyl, alkyl, cycloalkyl, styryl or aryl; R2 is hydrogen, alkyl, halogeno, hydroxyl, amino, cyclic amino or phenoxy; A is an optionally substituted homo- or hetero-cycle; R3 is a saturated nitrogenous heterocyclic group; and m is an integer of 0 to 3). The above compounds exhibit excellent production-inhibiting activities against TNF or IL- 1, thus being extremely useful as preventive or therapeutic agents for diseases due to these cytokines.

L'invention concerne des dérivés de 1H-imidazopyridine représentés par la formule générale (I), y compris leurs sels. Dans ladite formule, R?1¿ est hydrogène, hydroxyle, alkyle, cycloalkyle, styryle ou aryle; R?2¿ est hydrogène, alkyle, halogéno, hydroxyle, amino, amino cyclique ou phénoxy; A est un homocycle ou un hétérocycle éventuellement substitué; R?3¿ est un groupe hétérocyclique azoté saturé; et m est un entier dont la valeur est comprise entre 0 et 3. Les composés en question ont une excellente activité inhibitrice de production vis-à-vis du TNF ou de l'IL-1, ce qui les rend extrêmement utiles comme agents préventifs ou thérapeutiques pour le traitement de maladies résultant de la production des cytokines considérées.

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