1h-indazole-3-acetic acids as aldose reductase inhibitors

Details 1h-indazole-3-acetic acids as aldose reductase inhibitors 1h-indazole-3-acetic acids as aldose reductase inhibitors

C - Chemistry, Metallurgy

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C07D 403/06 (2006.01) A61K 31/41 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1335733

Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic complications. The 1H-indazole-3-acetic acid derivatives have the formula: Image (I) (wherein X1 and X2 are H, F, Cl, Br, CF3, alkyl or alkoxy; R is H or ester-forming group; R1 is Image , Image , Image , Image , Image , Image , Image or Image ; Y is S or O; X3 is H, F, Cl, Br, CF3, alkyl, alkoxy or Image X4, X5 and X6 are H, F, Cl, Br, CF3, alkyl or alkoxy; X3 and X4, taken together with the adjacent carbon atoms, may form a benzene ring) or pharmaceutically acceptable cationic or acid addition salts thereof.

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